Thursday, May 9, 2013

Terbutaline Sulfate

Terbutaline Sulfate
2.5mg Tablet
1.5mg/5ml Syrup

Drug Category: β-adrenergic Receptor Agonist (Anti-asthma)

Pharmacologic Action:
Terbutaline sulfate contains a sympathomimetic substance which stimulates β-adrenergic receptors of the sympathetic nervous system. Its main effect is relaxation of smooth muscles of the bronchial tree and peripheral vaculature.

For the relief of reversible bronchospasm in patients with obstructive airway disease, e.g., asthma, bronchitis, and emphysema.

Dosage and Administration:
Adults: 2.5mg three times daily to be increased to 5mg three times daily as necessary.
Pediatric Dose: Children's doses may be calculated on the basis of the body weight: a dose of 75mcg per kg three times daily. For children over 7 years of age 2.5mg two or three times daily or as prescribed by the physicians.

Patients who are known to be hypersensitive to sympathomimetic agents.

Terbutaline sulfate should be used with caution in patients with diabetes mellitus, hypertension, hyperthyroidism or cardiac disease especially those with associated arrhythmias. Discontinue use and consult a physician if decreased effectiveness and bronchoconstriction occurs.

Use in pregnancy and lactation:
Although no teratogenic effects have been observed in animals or in patients, caution is recommended during the first trimester of pregnancy. It passes into the maternal milk but the risk of influence on the child is unlikely with therapeutic doses.

Adverse Effect:
The most common observed adverse effects are tremor and nervousness. The frequency of side effects appear to diminish with continual therapy. Other reported reactions are headache, drowsiness, vomiting, nausea, sweating and muscle cramps. There are usually transient and do not require treatment.

Other sympathomimetic bronchodilators or epinephrine should not be used concomitantly with terbutaline sulfate, since their combined effects may be deleterious to the patients. It should be used with caution in patients being treated with MAOI or tricyclic antidepressants, since the action of terbutaline on the cardiovascular system may be potentiated.

Storage Condition:
Store at temperature not exceeding 30oC.

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